胃粘膜组织脂质过氧化物与胃粘膜损伤

LIPID PEROXIDE OF GASTRIC MUCOSA AND GASTRIC MUCOSAL LESION

测定了66例胃粘膜组织脂质过氧化物(LPO)含量。浅表胃炎、糜烂性胃炎及胃溃疡病变粘膜LPO水平较正常组织明显增高,但LPO水平与胃粘膜损伤程度无关。胃癌组织LPO亦较正常组织明显增高,但与其他胃粘膜损伤间无明显差别。结果表明,LPO参与了胃粘膜的损伤过程;测定胃良、恶性病变组织中LPO仅可作为胃粘膜受损伤的指标。

Lipid peroxide (LPO) levels in gastric mucosa of 66 cases were measured.LPO levels of gastric mucosa in superficial gastritis,erosive gastritis and gastric ulcer were elevated as compared with that of normal gastric mucosa,but not related with the gravity of gastric mucosa damage.It was also found that the LPO level in gastric cancer was increased over that of normal tissue,but there was no significant difference from other gastric lesions mentioned above.The result suggests that LPO may play a role in the process of gastric mucosal injury,and the LPO level in gastric mucosa may serve as a marker of damaged gastric mucosa in either benign or malignant gastric disease.