摘要
给雄性SD大鼠饮用含氟化钠(150mg/L)及同时分别加入不同浓度亚硒酸钠(0.5、2.0和4.0mg/L)的饮水共10周,观察氟及硒与氟联合作用对肾脏的脂质过氧化作用和微量元素铜、锌、铁含量的影响,以找出硒对氟毒性拮抗作用的最佳水平。结果表明,氟可使大鼠血清和肾组织脂质过化物含量明显增加,微量元素铜、锌、铁代谢紊乱。2.0mg/L亚硒酸钠对氟诱导的脂质过氧化具有显著的拮抗作用,对微量元素的改变也有明显的作用,而0.5和4.0mg/L时对氟毒性的拮抗作用均较差。因此,可以认为2.0mg/L亚硒酸钠是本实验条件下拮抗氟致肾损害的最佳水平。
ive groups of SD male rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and containing both 150 mg/L NaF and 0.5, 2.0 or 4.0 mg/L Na2SeO3 respectively for 10 weeks, in order to find out the optimal level of selenite in drinking water against fluoride toxicity. The results showed that fluoride could cause significant increase of lipid peroxides (LPO) and metabolic disorder of trace elements in the serum and kidney of rats. The antagonistic effect of 2.0 mg/L Na2SeO3 drinking water on the lipid peroxidation induced by 150 mg/LNaF was the most evident, whereas those of 0.5 and 4.0 mg/L Na2SeO3 were not obvious. It is concluded that selenite possesses significant antagonistic effects on renal damages induced by fluoride and 2.0 mg/L Na2SeO3 is the optimal concentration for the antagonistic effect on renal impairments induced by 150mg/L NaF in drinking water.
出处
《卫生研究》
CAS
CSCD
北大核心
1998年第3期201-204,共4页
Journal of Hygiene Research
基金
国家教委科研基金