小柴胡汤治疗慢性活动型肝炎的研究

TREATMENT OF CHRONIC ACTIVE HEPATITIS WITH CHINESE MEDICINE XCHT (MINOR DECOCTION OF BUPLEURUM)

自1986年11月至1988年6月对住院的成人患者经肝穿病理确诊为慢性活动型肝炎,并经血清学证实为乙型肝炎共86例,均符合1984年12月南宁全国肝炎会议制订的临床及病理诊断标准。随机分为3组:小柴胡汤组、小柴胡汤加联苯双酯组及联苯双酯组。3组连续服用药物3个月为一疗程。经临床观察,初步证明小柴胡汤与联苯双酯有相同的降低谷丙转氨酶的作用;12例患者中,有9例DNA多聚酶(DNA-P)阴转,治疗前后有显著差异(P<0.01),与动物实验结论一致。小柴胡汤对治疗慢性活动型肝炎有一定价值,值得进一步研究。

Eighty six patients with chronic active hepatitis admitted from Semptember 1986 to June 1988 were analysed in this study.All the 86 patients were proved histologically and serologically to be chro- nic active hepatitis conforming to the diagnostic criteria set by Symposium of Viral Hepatitis held in Nan-Ning,China (1984).The patients were randomly allocated into three groups:XCHT (minor decoction of Bupleurum),XCHT + BDD (biphenyl dimethyl dicarboxylate) and BDD groups.After a full course of 3-month treatment,it was demonstrated that the XCHT was as effective as BDD in normalizing the ALT activity,in addition,positive serum DNA-P in 9 out of 12 cases was converted into negative.These results were in agreement with that obtained from our animal experiments.The XCHT is considered to be a promising method for treatment of chronic active hepatitis and is worth for further study.