原发性喉软骨肉瘤临床病理分析

Clinicopathological analysis of primary laryngeal chondrosarcoma

目的研究喉软骨肉瘤的临床病理学特征、治疗及转归。方法对3例原发性喉软骨肉瘤临床病理资料进行回顾性分析。3例均为男性,年龄52～67岁,平均60.6岁,病程2～10个月,1例患者有长期吸烟史。肿瘤均有喉外侵犯,未发现颈淋巴结肿大和远处转移。术中冰冻切片检查诊断为软骨肉瘤,均行喉全切除术,未行颈淋巴结清扫。术后病理与冰冻结果一致。术后未行放、化疗。结果3例患者分别随访18、23、50个月,复查喉部CT均无瘤生存。结论喉全切除对较大喉软骨肉瘤具有较好疗效。

OBJECTIVE To investigate the clinicopathologic features treatment and turnover of the primary laryngeal chondrosarcoma. METHODS The clinical data of three patients with primary laryngeal chondrosarcoma were retrospectively investigated. All three patients were male and the mean age was 60.6 years old （ranged from 52 to 67） . The course of disease was 2 to 10 months. One of the patients had long-term history of smoking. All of the 3 patients underwent total laryngectomy without radiotherapy or chemotherapy postoperatively. The diagnosis of chondrosarcoma was confirmed by intraoperative frozen section examination. RESULTS No recurrence was detected by CT scan respectively at 18, 23 and 50 months follow-up. CONCLUSION Total laryngectomy may be efficient to control relatively larger laryngeal chondrosarcoma.