摘要
组织因子（tissue factor，TF）是体内引起血液凝固的强有力的启动因子，在止血、组织修复、血栓形成等一系列生理、病理过程中发挥重要作用。近年来，人们发现TF能够识别和调控细胞信号转导，促进血管新生、炎症反应，调节细胞黏附和运动，与恶性肿瘤侵袭、转移有着密切的联系。本文将对TF在恶性肿瘤转移中的作用做一综述。
Tissue factor is a powerful promoter of blood clotting in vivo, it plays an important role in hematischesis, tissue repair and thrombogenesis. In recent years, it is discovered that tissue factor can discriminate and regulate cell signal transduction, promote neogenesis of blood vessel and inflammatory reaction, regulate cell adhesion and movement, have a intimate relationship with invasion and metastasis of malignant tumor. In this article, we review the effects of tissue factor on malignant tumor metastasis.
出处
《国际外科学杂志》
2009年第5期347-350,共4页
International Journal of Surgery
关键词
组织因子
肿瘤
转移
tissue factor
tumor
metastasis
