流行性出血热各期心钠素与RAAS水平及其临床意义

ATRIOPEPTINS IN PLASMA OF PATIENTS WITH EPIDEMIC HEMORRHAGIC FEVER

对流行性出血热(EHF)42例患者血浆心钠素及肾素-血管紧张素Ⅱ-醛固酮(RAAS)水平进行了72例次观测,发现病程各期心钠素-肾素-血管紧张素Ⅱ-醛固酮系统均呈激发状态。血浆心钠素上升程度与病情一致,并与尿蛋白相关。初步探讨了心钠素与RAAS的关系及其在本病发生、发展中的作用和监控意义。

The level of atriopeptins and renin-and Ⅱ-aldosterone system (RAAS) in plasma of 42 patients' with epidemic hemorrhagic fever (EHF)were determined simultaneously by means of radioimmunoassay in our hospital.It was demonstrated that the level of atrial natriuretic factors and RAAS increased in all stages of the disease.The increased value of atriopeptins corresponded well with the severity of the disease and the increased urine protein content.The relationship of atriopeptins to RAAS and their effects in the pathogenesis and monitoring of this disease are further discussed and evaluated.