CTLA4基因多态性与汉族人白癜风易感性相关分析

Association between polymorphism of CTLA4 gene and vitiligo susceptibility in Chinese Han population

目的研究汉族人CTLA4基因多态性与白癜风易感性的相关性。方法利用Illumina 610-Quad芯片对1123例白癜风患者和1227例正常对照样本进行基因分型,提取CT-LA4基因的相关分型数据,用Plink1.03软件进行统计分析。结果CTLA4基因上2个SNP位点(rs733618和rs231726)的等位基因频率在病例组和对照组之间的差异无统计学意义(P>0.05)。结论CTLA4基因多态性与汉族人白癜风易感性可能无关联。

Objective To study the association between CTLA4 gene and vitiligo in Chinese Han population. Methods The genotyping was done by using the Illumina Human 610-Quad BeadChips in 1 123 cases of vitiligo and 1 227 controls, then we selected genotyping data on CTLA4 gene、 Statistical analysis was performed by the Plink 1.03 software. Results It showed that the differences of 2 SNPs （rs733618 and rs231726） on CTLA4 gene between cases and controls had not statistically significant （ P 〉 0. 05 ）. Conclusion The results suggest that the CTLA4 gene may not be associated with the susceptibility of vitiligo in Chinese Hart population.