LCE3D基因多态性与汉族人寻常型银屑病表型的相关性研究

Correlation of rs4085613 polymorphism within the late cornified envelope 3D gene with some clinical features of psoriasis vulgaris in Chinese Han population

目的探讨LCE3D基因多态性rs4085613位点与汉族人寻常型银屑病临床表型(发病年龄、家族史及临床类型)的相关性。方法选取1139例患者和1132例正常对照的LCE3D基因多态性rs4085613位点基因分型资料(基因分型采用Illumina 610芯片)。χ2检验用于比较各组间基因型和等位基因频率的分布。结果病例组与对照组间LCE3D基因多态性rs4085613位点基因型和等位基因频率分布差异具有统计学意义(P<0.05)。少儿发病患者与成人发病患者、家族史阳性患者与阴性患者、急性点滴型患者与慢性斑块型患者之间的基因型和等位基因频率分布差异均无统计学意义(P>0.05)。结论LCE3D基因rs4085613遗传多态性与汉族人寻常型银屑病的易感性相关,但与发病年龄、家族史及临床类型可能无明显相关性。

Objective To compare the genotype distribution of rs4085613 polymorphism within LCE3D gene with some clinical features of psoriasis vulgaris in Chinese Han population. Methods We analyzed the distributions of genotype and allelic frequencies of rs4085613 polymorphism in 1 139 cases and 1 132 normal controls. The rs4085613 was genotyped by using the Illumina Human 610-Quad BeadChips. Chi square test was used for testing the genotype or allele frequency distribution in cases and controls. Results The study showed that genotype and allelie frequencies of rs4085613 polymorphism within LCE3D gene had statistical significance between the cases and the controls （both P 〈 0. 05 ）. However, there weren＇t statistical significance between the pediatric age of onset and adult age of onset cases, between the familial and sporadic cases and between the guttate and plaque cases （ all P 〉 O. 05）. Conclusion The findings indicate the rs4085613 polymorphism within LCE3D gene couldn＇t associate with the age of onset, family history and clinical type of psoriasis vulgaris in Chinese Han population.