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前列腺癌的表观遗传学机制 被引量：2

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摘要 目前认为，基因改变如突变和表观遗传学改变是前列腺癌（PCa）恶性转化和进展的2大机制，其中表观遗传学机制如DNA甲基化及组蛋白修饰在PCa发生发展以及雄激素非依赖性前列腺癌（AIPC）形成中具有重要作用，并且由于其改变的可逆性，可能成为PCa诊断和治疗的新靶点。现就PCa的表观遗传学机制综述如下。
作者 王小海 夏术阶
机构地区 上海交通大学附属第一人民医院泌尿外科
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2009年第6期425-428,共4页 Chinese Journal of Urology
关键词 非依赖性前列腺癌 遗传学机制 DNA甲基化 遗传学改变 组蛋白修饰 恶性转化 基因改变 Ca诊断
分类号 R686 [医药卫生—骨科学]
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参考文献25

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二级参考文献6

共引文献18

同被引文献39

  • 1王震,王芳,魏万里,高倩,王维琦,杨耘,王国英.NDRG1基因在结直肠癌发生发展过程中的表达及其与淋巴结转移的关系[J].中华病理学杂志,2004,33(3):264-265. 被引量：17
  • 2朱进,单玉春,阳东荣.膀胱癌中DNA甲基转移酶1表达的实时定量检测[J].中华泌尿外科杂志,2008,29(12):28-30.
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中华泌尿外科杂志
2009年 第6期

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