儿童白癜风与甲状腺功能指标异常及其他免疫性疾病的关系

Abnormality of parameters of thyroid function and incidence of autoimmune diseases in children with vitiligo

目的探讨儿童白癜风与甲状腺功能指标异常及其他免疫性疾病的关系。方法对363例白癜风儿童（男198例，女165例）和93例对照儿童（男55例，女38例）进行甲状腺功能指标的检查。结果363例白癜风儿童中有43例（11．8％）儿童有不同程度的甲状腺功能指标的异常，93例对照组正常儿童中有4例儿童甲状腺功能指标异常，两者比较差异有统计学意义。白癜风儿童甲状腺功能指标异常发生率明显增高（P〈0．05）。而43例甲状腺功能异常的白癜风儿童中，寻常型白癜风儿童为39例（13．6％），节段型白癜风儿童为4例（5．3％），寻常型比节段型白癜风儿童甲状腺功能指标异常发生率有明显增高（P〈0．05）。结论儿童寻常型白癜风患者的甲状腺功能指标异常的发生率明显增高。

Objective To investigate the abnormality of parameters of thyroid function and incidence of autoimmune diseases in children with vitiligo. Methods A total of 363 children with vitiligo, including 198 males and 165 females were recruited into this study together with 93 normal human controls （55 males and 38 females）. The serum levels of flee tetraiodothyronine, free triiodothyronine, thyroid stimulating hormone, antithyroperoxidase antibody and thyroglobulin antibody were determined by chemiluminescent immunoassay in these subjects. Results The abnormality of parameters of thyroid function was observed in 43 out of 363 （11.8% ） patients affected by vitiligo and in 4 out of 93 （4.3%） normal human controls; a significant difference was observed between the two groups （P 〈 0.05）. Of the 43 patients with abnormality of parameters of thyroid function, 39 were diagnosed as vitiligo vulgaris, 4 as segmental vitiligo. A significant increase was observed in the incidence of abnormality of parameters of thyroid function in patients with vitiligo vulgaris compared with those with segmental vitiligo （P 〈 0.05 ）. Conclusion There is an increase in the abnormality of parameters of thyroid function in children with vitiligo.