头孢曲松致过敏性休克70例文献分析

Analysis of Literature about Ceftriaxone-induced Anaphylactic Shock in 70 Cases

目的:探讨头孢曲松引起过敏性休克的特点、相关因素及预防措施,为临床安全用药提供参考。方法:利用"中文期刊全文数据库"、"中文科技期刊全文数据库"和"万方数据医药信息镜像系统",对1994～2007年12月国内医药学期刊发表的文献进行检索,检索到头孢曲松致过敏性休克病例70例,对病例的资料进行整理、统计与归纳。结果:男43例(61.4%),女27例(38.6%);其中静脉给药64例(91.4%),肌注及前列腺膜下注射6例(8.6%);休克多发生在用药后20min以内(71.2%);治疗后61例康复(87.1%),8例死亡(11.4%),1例植物人(1.5%)。结论:头孢曲松过敏性休克发生迅速,应注意及时抢救。用药前应仔细询问病史和用药史,以减少休克的发生。

Objective： To study the characteristics, related factors and precautionary measures of ceftriaxone-induced anaphylaetic shock, and provide reference for clinical safe medication. Method： The literature between January, 1994 and December, 2007 was collected from Chinese Journal Full-text Database, Chinese Science and Technology Journal Full-text Database, and Wanfang Medicine Data China info, 70 cases with ceftriaxone-indueed anaphylactic shock were reviewed and analyzed. Result： Of the 70 cases, 43（61.4% ） were male, and 27（38.6% ） were female. 64（91.4% ） received intravenous fusion or intravenous injection and 6（ 8.6% ） , intramuscular or prostate capsule injection. Most of the anaphylactic shock cases occurred within 20 minutes （71.2%） after administration. 61 cases recovered （87.1% ） and 8 cases died（ 11.4% ） and 1 cases became vegetable （ 1.5 % ） after treatment. Conclusion： The c eftriaxone-induced anaphylactic shock is rapid so as to be timely rescued. Patients should be asked about their case history and medication history in detail before treatment in order to reduce occurrences of shock.