急性心肌梗死患者C反应蛋白浓度变化与梗死面积的相关性研究

The research of the correlation between C-reactive protein concentration of AMI and infarct size

目的通过磁共振延迟强化成像（DE—MRI）技术定量评估急性心肌梗死（AMI）患者存活心肌和梗死面积，探讨AMI患者C反应蛋白浓度的高低与心梗面积的相关性。方法采用免疫荧光比浊法检测40例AMI患者血清CRP水平。将AMI患者分成高CRP组和低CRP组，并对所有患者行DE—CMRI定量分析梗死面积，研究其与CRP浓度之间相关性。结果AMI高浓度CRP患者与低浓度CRP相比在心脏梗死质量，梗死百分比，灌注缺损段及室壁运动评分比较差异有统计学意义，高浓度CRP患者在梗死质量和面积上远较低浓度CRP者大。结论急性心肌梗死后梗死面积和质量与CRP浓度成正比关系。

Objective To quantitative assessment myocardial necrosis of acute myocardial infactions using delayed contrast-enhanced magnetic resonance imaging （ DE-MRI）, To investigate the correlation between infarct size as assessed by DE-MRI, and C-reactive protein concentration. Methods The CRP level of forty patients with AMI patients were detected. Patients were divided into high CRP subgroup and low CRP subgroup according to hsCRP levels. To investigate the correlation between two groups patients C-reactive protein concentration and infarct size as assessed by DE-MRI. Results High CRP sub- group was significant higher than that of low CRP subgroup in infact size,infact mass, perfusion-defect segments,and wall motion （P 〈 0.05 ）. Conclusion The CRP concentration is correlated well with infarct size and infarct mass.