尿视黄醇结合蛋白检测在高血压伴餐后高血糖患者中的临床意义

The clinical importance of investigating the urine retinal binding protein in hypertension patients with impaired glucose tolerance

目的测定高血压伴餐后高血糖患者尿视黄醇结合蛋白（RBP）水平，探讨其临床意义。方法用酶联免疫法测定61例高血压伴餐后高血糖患者和76例单纯高血压患者尿RBP，同时进行血压监测。结果单纯高血压组和高血压伴餐后高血糖组尿RBP均高于正常对照组，且以后者为著（P〈0．01），单纯高血压组24小时血压与高血压伴餐后高血糖组对比，后者夜间血压负荷和全天舒张压负荷均高于前者（P〈0．01），且后者夜间血压负荷均大于白天血压负荷。结论轻、中度高血压患者已存在肾小管损害，并存IGT可加重其损害程度，降压的同时加强对IGT的干预可能会对保护高血压患者。肾功能有益，尿RBP检测可做为评价肾小管损害的早期敏感指标之一。

Objective To investingate the urine retinal binding protein （RBP） in hypertension patients with impaired glucose tolerance（IGT）. Methods The urine RBP of 76 cases of essential hyperension arid 61 cases of cssential hypertension with IGT was measured. 24h blood pressure was examined. Results The urine RBP in two groups was significantly higher than that in control group, expeeially in hypertension with IGT group（ P 〈 0.01 ） meanwhile ,24h Diastolic Blood Pressure（DBP） load and Night Diastolic Blood pressure（NDBP） load were much higher. Conclusion Renal ubular function has been damaged in the mild to moderate hypertension, and IGT can make it more serves. It could have a better protection for renal function to treat hypertension and IGT. The urine RBP is an indicator of the diagnosis of the early renal injury.