益肾中药复方防治大鼠继发性骨质疏松症的实验研究

Treatment and protection of secondary osteoporosis in rats with "Kidney-Tonifying" Chinese herb compound

目的:益肾中药复方用于实验性继发性骨质疏松症模型大鼠,观察其疗效,并对中药复方的机制做初步的探讨.方法:使用糖皮质激素肌肉注射制造继发性骨质疏松症动物模型,同时给予益肾中药复方治疗3mo后,观察模型动物股骨骨密度(BMD)、血钙、血磷、血碱性磷酸酶(AKP)理化指标.结果:益肾中药复方治疗组大鼠股骨BMD高于模型组(P<0.05),血钙、血磷、血AKP等均高于模型组(P<0.05).结论:益肾中药复方能在一定程度上缓解由糖皮质激素诱发的骨质疏松症.

AIM： To observe the effect of ＂ Kidney-Tonifying＂ Chinese herb compound on rats with secondary osteoporosis and to explore its mechanism. METHODS： By intramuscular injection of dexamethasone, the animal model of secondary osteoporosis was made and the animals were then given ＂Kidney-Tonifying＂ Chinese herb compound for 3 months. Bone mineral density（BMD） of femur and serum Ca, P and AKP were determined. RESULTS： The BMD of femur and the values of serum Ca, P and AKP in Chinese herb compound group were higher than those in control group （P 〈 0.05 ）. CONCLUSION ： ＂Kidney-Tonifying＂ Chinese herb compound to some extent alleviates secondary osteoporosis.