期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

PXR基因多态性的研究现状及其对环孢素A的药物相互作用的预测意义 被引量：2

下载PDF
导出
摘要 环孢素A作为广泛应用于器官移植术后的免疫抑制剂,狭窄的治疗窗、显著的药动学个体差异,尤其是药物联用情况下的初始剂量选择是众多学者关注的问题.CYP3A4显著的表型差异是造成环孢素A药动学差异的主要原因.核受体PXR作为CYP3A4以及P糖蛋白编码基因的上游调控关键因子,其自身基因序列的突变可能是导致下游基因转录活性发生改变的分子机制.因此,从PXR的基因入手,探索环孢素A的最佳初始剂量,将为器官移植患者提供更加准确的治疗方案.
作者 曾勇 周宏灏
机构地区 中南大学临床药理研究所
出处 《第四军医大学学报》 北大核心 2009年第11期1051-1054,共4页 Journal of the Fourth Military Medical University
基金 国家自然科学基金(30300428)
关键词 核受体PXR 基因多态性 环孢素A 药物相互作用
分类号 R969.2 [医药卫生—药理学]
  • 相关文献

参考文献26

  • 1Eineke G, Schutz M, Mai I, et al. Limitations of C2 monitoring in renal transplant recipients [ J ]. Transplantation, 2005, 20 ( 7 ) : 1463 - 1470.
  • 2Gonzalez FJ, Yu AM. Cytochrome P450 and xenobiotic receptor humanized mice [ J ]. Ann Rev Pharmacol Toxicol, 2006, 46:41 -64.
  • 3Wang XD, Deng XY, Chen J. Single nucleotide polymorphisms of the pregnane X receptor gene in Han Chinese and a comparison with other ethnic populations [ J ]. Pharmacology, 2008, 81 ( 4 ) : 350 - 354.
  • 4Bosch TM, Deenen M, Pruntel R, et al. Screening for polymorphisms in the PXR gene in a Dutch population [ J ]. Eur J Clin Pharmacol, 2006, 62(5): 395-399.
  • 5Wang XD, Li JL, Su QB, et al. A phannacogenetie study of pregnane X receptor (NR1 I2) in Han Chinese [ J]. Curr Drug Metab, 2007, 9 : 778 - 786.
  • 6Eamba J, Lamba V, Strom S, et aL Novel Single Nucleotide Polymorphisms in the Promoter and Intron 1 of Human Pregnane X Receptor/NRlI2 and Their Association with CYP3A4 Expression [ J]. Drug Metab Dispos, 2008, 36( 1 ) : 169 - 181.
  • 7Lim YP, Liu CH, Shyu LJ, et al. Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects [J]. Pharm Gen, 2005,15(5) : 337 -341.
  • 8Koyano S, Kurose K, Saito Y, et al. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR) : One variant cause dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region [ J]. Drug Metab Dispos, 2004,32 : 149 - 154.
  • 9Ikemura K, Urano K, Matsuda H, et al. Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats : The contribution of CYP3A4 and P-glycoprotein to the first-pass metabo- lism in intestinal epithelial cells [J]. Pharmacol Exp Ther Fast For- ward, 2009, 328 : 249 - 255.
  • 10Li H, Jin HE, Kim W, et al. Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in caco-2 and MDCK II cells [J]. Pharm Res, 2008, 25 (11) : 2601 -2612.

同被引文献49

  • 1汪晖.P-糖蛋白介导的药物疗效和毒性改变[J].咸宁学院学报（医学版）,2004,18(5):305-307. 被引量：4
  • 2刘治军,傅得兴,孙春华,迟家敏,张亚同.体内药物相互作用研究进展[J].药物不良反应杂志,2006,8(1):33-38. 被引量：63
  • 3Stangier J,Su CA,Hendriks MG,et al.The effect of telmisartan on the steady-state pharmacokinetics of digoxin in healthy male volunteers[J].Journal of Clinial Pharmacology,2000,40(12):1373-1379.
  • 4Staudinger JL, Ding X, Lichti K. Pregnane X receptor and natural products: beyond drug-drug interactions[J]. Expert Opin Drug Metab Toxicol, 2006,2 (6) : 847.
  • 5余春娜.核受体介导的中药对药物代谢酶的诱导作用研舟[D].杭州:浙江大学药学院,2008.
  • 6Luckert C, Ehlers A, Buhrke T, et al. Polycyclic aromat-ic hydrocarbons stimulate human CYP3A4 promoter ac- tivity via PXR[J]. ToxicolLett, 2013, 222(2) : 180.
  • 7Wang YM, Lin W, Chai SC, et al. Piperine activates hu- man pregnane X receptor to induce the expression of cyto- chrome P~0 3A4 and multidrug resistance protein l[J]. Toxicol etppl Pharmacol, 2013,272 ( 1 ) : 96.
  • 8Kojima H, Sara F, Takeuchi S, et al. Comparative study of human and mouse preguane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays[J]. Toxicology, 2011,280 ( 3 ) : 77.
  • 9Mnif W, Pascussi JM, Pillon A, et al. Estrogens and anties- trogens activate hPXR[J]. Toxicol Lett, 2007,170( 1 ) : 19.
  • 10Kuzbari O, Peterson CM, Franklin MR, et al. Compara- tive analysis of human CYP3A4 and rat CYP3A1 induc- tion and relevant gene expression by bisphenol A and di- ethylstilbestrol: implications for toxicity testing para- digms[J]. Reprod Toxicol, 2013,37 : 24.

引证文献2

第四军医大学学报
2009年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部