细胞间黏附分子-1在早产胎膜早破中的表达及临床意义

The Expression and Clinical Significance of Intercellular Adhesion Molecule-1 in Premature Rupture of Membranes

目的:研究细胞间黏附分子-1(ICAM-1)在早产胎膜早破中的表达及临床意义。方法:选取38例早产胎膜早破(PPROM)孕妇为研究组(PPROM组),36例与PPROM组孕周相对应之胎膜完整的自发早产(PTL)孕妇为对照组(PTL组),应用SP法检测各组胎膜ICAM-1的表达,并进行临床病理的相关性分析。结果:PPROM组中有55.26%(21/38)存在绒毛膜羊膜炎,PTL组中为36.11%(13/36),两组比较差异有统计学意义(P<0.05);两组胎膜中均存在不同程度的ICAM-1阳性表达,两组比较差异有统计学意义(P<0.05),PPROM组和PTL组ICAM-1的阳性表达与绒毛膜羊膜炎的相关系数分别为0.90和0.72,且病理结果中炎症越重的患者其胎膜上ICAM-1的阳性表达越明显。结论:ICAM-1的表达与感染相关,异常表达在早产胎膜早破的发病过程中起一定作用。感染越重的患者,ICAM-1的表达越明显,提示妊娠结局的严重化。

Objective：To study the expression and clinical significance of intercellular adhesion molecule-1 （ICAM- 1） in preterm premature rupture of membranes. Methods：38 cases of premature rupture of membranes were cho- sen for the study group （ PPROM group）, 36 cases of spontaneous premature delivery with intact fetal membrane whose gestational weeks were correspond to the study group as the control group （ PTL group）. SP method was used to detect the ICAM-1 expression of fetal membrane in each group and the clinical and pathological dependability was analyzed.Results：There were different positive expression degrees of ICAM-1 in fetal membrane in both two groups, and the difference between the two groups was significant （ P〈 0.05）. 21 （55.26%） cases were proved to be chorioamnionitis in PPROM group, 13（36.11 ）% cases in PTL group, the difference between the two groups was significant（ P 〈 0.05）. The correlation coefficient between ICAM-1 expression and chodoamnionitis in PPROM group is 0.90, and 0.72 in PTL group. The more severe inflammation was found in pathological cases, the more obvious positive expression of ICAM-1 was expressed. Conclusions.The expression of ICAM-1 is associated with infection, and its abnormal expression play a role in the pathogenesis of premature rupture of membranes. The more severe infection, the more obvious positive expression of ICAM-1 in gravida suggests that more serious pregnancy outcome.