急性心肌梗塞患者尿激酶治疗前后血浆组织型纤溶酶原激活物及抑制物活性变化的动态观察

A DYNAMIC STUDY OF PLASMA t-PA,PAI ACTIVITY AND ACTIVE TYPE t-PA IN AMI PATIENTS BEFORE AND AFTER TREATMENT WITH UROKINASE

测定了急性心肌梗塞(AMI)20例患者血浆组织型纤溶酶原激活物(t-PA)及抑制物(PAI)的活性变化,并对11例尿激酶(UK)治疗的患者进行了上述指标的动态观察。结果:心肌梗塞组与正常组比较,血浆t-PA活性无变化,PAI活性显著升高(P<0.001);UK治疗前后观察,通过方差分析,上述指标差异非常显著。结果提示:PAI在血栓形成中有重要的病理意义;UK溶栓治疗能够改善机体自身纤溶系统的稳定性。

Tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor (PAD activity were determined in 20 patients with myocardial infarction (MI).In another 11 patients,who were treated with urokinase (UK).t-PA and PA1 were also sequentially determined.The results showed that there was no difference of t-PA between patients with MI and normal controls,whereas PAI activity was much higher in patients with MI.In patients treated with UK the values of these two parameters of coagulation before treatment were significantly different from that of parameter after treatment.The results suggest that PAI plays an important role in thrombosis,and UK treatment can improve the stability of fibrinolytic system.