面向心血管应用的电子束蒸发氧化钛薄膜的特性——润湿性与血液相容性

Characteristics of the TiO_x Films Deposited by E-beam Evaporation for Cardiovascular Applications:Hydrophilicity and Hematypic Compatibility

用电子束蒸发的方法在钛盘上沉积氧化钛薄膜以检验其在心血管支架方面的应用.用接触角仪测定水滴在所制备氧化钛薄膜表面的接触角,随着沉积过程中氧气流量的增加,薄膜的接触角不断降低,经过热处理后薄膜的亲水性得到了增强.通过观察猪主动脉平滑肌细胞(PASMC)在样品表面的生长行为,研究薄膜的结构与细胞活性的关系.结果表明,覆有薄膜的钛盘具有更好的生物相容性,而沉积后的热处理能够进一步改善氧化钛薄膜的生物相容性.通过观察血小板的吸附行为研究薄膜的血液相容性,发现在所制备的氧化钛薄膜上吸附了极少的血小板.研究结果表明,用电子束蒸发制备的氧化钛薄膜能够用于心血管支架的表面改性.

TiOx thin films were deposited on commercial Ti discs by E-beam evaporation and they were tested for their applications to cardiovascular stents. A goniometer was used to measure the contact angle of a drop of water falling onto the prepared thin film. It was found that the angle decreases with the increasing O2 flow rate in film depositing process and, after heat-treatment, the hydrophilicity of film is improved. Investigates the relationship between film structure and cellular activity via observing the growth behavior of PASMC（porcine aortic smooth muscle cells） on film samples. The results revealed that the Ti discs coated with the TiOx films have higher biocompatibility which can be improved further by the heat-treatment after film deposition. The hematypic compatibility of the films was studied via observing the adsorption behavior of platelets and it is found only few platelets are adsorbed onto the films. In conclusion, the TiOx thin films deposited by E-beam can be applied to the surface modification of cardiovascular stents.