肾上腺糖皮质激素在狼疮性肾炎治疗中的合理应用

The rational use of corticosteroids in the treatment of lupus nephritis

活动性系统性红斑狼疮及狼疮性肾炎常用肾上腺糖皮质激素联合免疫抑制剂作基础治疗,其中危重患者在此基础上还需加甲泼尼龙冲击强化治疗来迅速顿挫狼疮活动。本文拟对激素种类、常规治疗及冲击治疗方案、副反应及治疗目标做一详细讨论,以帮助临床医师合理用药。

Active systemic lupus erythematosus （ SLE ） and lupus nephritis （ LN ） are often treated with corticosteroids combined with various immunosuppressives. For the critical patients the methylprednisolone plus intensive therapy should be also used on the basis of above-mentioned routine treatment in order to abort the severe activity of SLE/LN rapidly. In this paper the sorts, the routine and intensive therapeutic regimens, the side-effects and the treatment targets of corticosteroids will be reviewed in detail.