低钙透析液对血液透析过程中血压升高患者血压血钙及内皮素的影响研究

Effects of low calcium concentration dialysate on blood pressure,ionized calcium and serum endothelin-1 of uremic patient with hypertension during hemodialysis

目的研究低钙离子浓度透析液对维持性血液透析患者透析过程中血压、血清钙离子(Ca2+)、内皮素(ET-1)的影响。方法选择2007年3月至2008年3月中国医科大学附属盛京医院60例透析过程中血压升高的尿毒症患者,先后使用钙离子浓度为1.75mmol/L(DCa1.75)和1.25mmol/L(DCa1.25)的透析液进行血液透析,监测透析前后血压、血Ca2+、ET-1的变化。结果透析过程中血压升高的尿毒症患者应用DCa1.75的透析液,透析后的血压、血Ca2+、ET-1比透析前以及使用DCa1.25的透析液透析后血压、血Ca2+、ET-1浓度均明显升高(P<0.05)。结论应用低钙透析液能够避免高钙透析液导致的血液透析过程中血压升高问题。

Objective To evalute effects of low calcium concentration dialysate on blood pressure,ionized calcium and serum endothelin-1 of uremic patient with hypertension during hemodialysis. Methods 60 uremic patients with hypertension during hemodialysis in the Shengjing Hospital of China Medical University were dialysated with different calcium concentration（ 1.75 mmol/L followed by 1.25 mmoL/L）. TO measurearterial blood pressure ,ionized calcium and serum endothelin-1 before and after each dialysis session. Results The post-dialysis blood pressure,ionized calcium and serum endothelin-1 level of uremic patients using DCa1. 75 with hypertension during hemodialysis were increased significantly than those of pre-dialysis and post-dialysis with DCa1. 25 （ P 〈 0.05 ）. Conclusion The DCa1. 25 can reduces uremic patient hypertension which is higher with DCa1. 75 during hemodialysis.