原发性胆汁淤积性肝硬化治疗进展

Research advance on primary biliary cirrhosis

原发性胆汁淤积性肝硬化(PBC)是一种多发于中年女性、不明原因导致的慢性进行性胆汁淤积性肝脏疾病。熊去氧胆酸(UDCA)是目前公认的对PBC具有确切疗效的首选治疗药物,免疫抑制剂与其联合治疗是目前研究的热点。肝移植仍是终末期PBC的惟一治疗手段。

Primary biliary cirrhosis（PBC） is a chronic,progressive cholestatic liver disease of unknown cause that usually affects middle-aged women. Ursodeoxycholic acid（UDCA） is the first selected drug to PBC which has definite effect. Treament of PBC with UDCA combined with immunodepressant become presents research focuses. Liver transplantation is the only treatment of the final stage of PBC.