甲状腺滤泡状癌微淋巴管密度与淋巴结转移的关系

Relationship between micro-lymphatic vessel density and lymphatic metastasis in follicular thyroid carcinoma

目的:应用新型淋巴管内皮标记物D2-40分析甲状腺滤泡状癌及周围组织微淋巴管密度(MLVD)与淋巴结转移之间的关系。方法:应用免疫组织化学Envision法检测35例甲状腺滤泡状癌和20例结节性甲状腺肿中D2-40和CD34的表达,分别计数MLVD和微血管密度(MVD),分析MLVD与甲状腺滤泡状癌淋巴结转移之间的关系,同时与病变中MVD行对比观察。结果:甲状腺滤泡状癌周围结缔组织及被膜中的MLVD和MVD与淋巴结转移有密切关系;MLVD和MVD越高淋巴结转移率越高。同时甲状腺淋巴管内的癌栓与淋巴结转移也显著相关(P<0.01)。结论:甲状腺滤泡状癌的淋巴结转移与微淋巴管及微血管的形成有密切关系,抑制淋巴管生成,这可能是未来甲状腺肿瘤治疗的一重要方向。

AIM：To investigate the relationship between micro-lymphatic vessel density （MLVD） and lymphatic metastasis in follicular thyroid carcinoma （FTC）. METHODS：MLVD and micro-vascular density （MVD） were determined and counted by Envision immunohistochemistry using D2-40 and CD34 monoclonal antibodies in 35 specimens of follicular thyroid carcinoma（FTC）and 20 of nodular goiter. The relationship between MLVD and lymphatic metastasis was analyzed. RESULTS：MLVD and MVD in follicular thyroid carcinoma were closely related with lymphatic metastasis. At the same time,the cancer embolus in the micro-lymphatic vessel was significantly related with the lymphatic metastasis （P〈0.01）. CONCLUSION：The metastasis process of follicular thyroid carcinoma（FTC）is associated with the formation of the micro-lymphatic vessel and micro-vascular. Inhibition of the lymphatics formation may be a potential therapeutic maneuver for thyroid neoplasms in the future.