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老年糖尿病酮症酸中毒患者IL-6和氧化应激的变化 被引量：4

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摘要 目的:探讨老年糖尿病酮症酸中毒(DKA)患者白细胞介素6(IL-6)和氧化应激的变化。方法:检测老年糖尿病酮症酸中毒患者治疗前后血IL-6、8-异前列腺素F2α(8-iso-prostaglandinF2α,8-iso-PGF2α)水平、超氧化物歧化酶(SOD)活性、总抗氧化能力(TAC)和丙二醛(MDA)含量。结果:在DKA患者SOD、TAC显著低于对照组(P<0.05),而IL-6、MDA和8-iso-PGF2α显著高于对照组(P<0.05);DKA患者治疗后的SOD和TAC显著高于治疗前患者(P<0.05),而IL-6、MDA和8-iso-PGF2α显著低于治疗前患者(P<0.05)。DKA患者治疗前IL-6与8-iso-PGF2α呈显著性正相关(r=0.33,P<0.05),治疗后IL-6与SOD呈显著性负相关(r=-0.36,P<0.05)。DKA患者治疗前后IL-6与MDA均呈显著性正相关(r=0.38,0.41,P<0.05)。结论:DKA患者血清IL-6水平明显升高,且与氧化应激有关。
作者 李娟 沈兴平 邹森彪 吴豪杰
机构地区 厦门大学附属中山医院急诊科重症监护室 厦门大学附属中山医院内分泌科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2009年第6期537-539,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 厦门卫生局医学科研基金资助项目(WSK0524)
关键词 糖尿病酮症酸中毒 白细胞介素6 氧化应激
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献10

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二级参考文献15

  • 1沈兴平,李娟,严钟德.肥胖2型糖尿病患者血清E-选择素水平与氧化应激的关系[J].中国病理生理杂志,2006,22(10):2040-2043. 被引量：12
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共引文献21

同被引文献28

二级引证文献23

细胞与分子免疫学杂志
2009年 第6期

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