HBV血清型和基因型与母婴传播关系的研究

Study on the relation between hepatitis B virus serotypes and genotypes and mother-infant transmission

【目的】探讨乙型肝炎病毒(hepatitis Bvirus,HBV)血清型、基因型与HBV母婴传播的关系。【方法】100份HBsAg阳性孕产妇及其新生儿的外周血,发生母婴传播血清为病例组,其他为对照组。ELISA法检测乙肝系列,根据S基因判断HBV血清型和基因型。【结果】99份HBV血清型全为adw型;39例发生母婴传播HBV基因C型25例;B型13例;E型1例。60例未发生母婴传播,HBV基因B型50例;C型10例。两组HBV基因分型结果差异有显著性(P<0.05)。【结论】HBV母亲C基因型可能更易发生母婴传播。

[Objective] To investigate the hepatitis B virus （HBV） serotypes and genotypes in mother-infant transmission. [Method] A total number of 100 serum samples were collected from mothers and infants,which were divided into two groups： the serum samples with mother-infant transmission （case group）and the others （control group）. Hepatitis B marks were detected by ELISA. The serotypes and genotypes were analysed through HBV S gene. [Results] The HBV serotype in 99 patients was all adw. Among 39 patients with mother-infant transmission,25 patients were genotype C,13 patients were genotypes B, 1 patient was genotype E. Among 60 patients without mother-infant transmission,50 patients were genotype B,10 patients were genotype C. The geontypes had significant differences between the two groups（P〈0. 05）. [Conclusion] HBV genotype C might contribute to the mother-infant transmission.