口腔扁平苔癣患者焦虑和唾液皮质醇水平相关性研究

Study of Anxiety and Salivary Cortisol Levels in Patients with Oral Lichen Planus

目的探讨口腔扁平苔癣（0LP）患者焦虑和唾液皮质醇之间的关系。方法使用化学发光法检测0LP患者和对照组唾液皮质醇水平，使用Spielberger焦虑量表评定两组人群的焦虑状态和焦虑特性。结果56例0LP患者唾液皮质醇平均浓度为1．32μg／dl，60例对照组为0．97,ug／dl（P〈0．001）；OLP组平均焦虑状态评分和平均焦虑特性评分分别为46．78和49．89，对照组分别为39．98和39．21（均P=0．001）。唾液皮质醇水平、焦虑状态和特性评分显著高于对照组。唾液皮质醇水平、焦虑状态和特性水平与OLP显著相关（P值分别为0．02，0．04，0．03）。结论OLP发病与精神紧张密切相关，OLP患者存在明显心理异常，因此，对OLP患者进行传统治疗的同时要进行心理治疗。

Objective To study the association between anxiety and salivary cortisol levels in patients with oral lichen planus （OLP）. Methods Salivary cortisol was examined with Beckman Access instrument in both groups ;State/trait anxiety was scored with Spielberger＇s State-Trait Anxiety Inventory. Results The mean level of eortisol from 56 saliva samples in study group were 1.32 and 0.97 μg/dl in 60 controls （P〈0. 001） respectively. The mean scores of state anxiety in the study group were 46.78 and 39.98 in control group （P=0. 001） respectively. Trait anxiety levels in study group were 49.89 and 39.21 in control group （P〈0. 001） respectively. Salivary cortisol, state and trait anxiety levels in OLP group were significantly higher than in the control group. Salivary cortisol levels,state and trait anxiety were markedly related to OLP （P=0. 02,P=0. 04 and P=0.03,respectively）. Conclusion Oral lichen planus is closely related with stress,OLP patients have obvious mental disorder. There fore, suggest that treatment of OLP patients includes both conventional medicine and psychological care.