依达拉奉治疗48例急性脑出血的疗效评估

The evaluate of therapeutic effects of Edaravone in 48 patients with acute cerebral hemorrhage

目的观察依达拉奉对急性脑出血的临床疗效。方法将96例脑出血患者随机均分为治疗组和对照组,对照组48例采用常规治疗;治疗组48例在常规治疗的基础上给予依达拉奉应用共14天。两组均在治疗前及治疗后20天进行神经功能缺损评分、疗效评定及血清C-反应蛋白(CRP)含量测定。结果治疗组在20天后神经功能缺损评分改善明显优于对照组;疗效(有效率89%)优于对照组(有效率78%);治疗组CRP异常率(41.38%)显著低于对照组(54.35%)。结论依达拉奉可以减轻急性脑出血的炎症反应,降低神经功能缺损程度。

Objective To observe the effect of edaravoneon on the treatment of acute cerebral hemorrhage. Methods 96 cases were divided into treatment group and control group randomly, 48 cases of control group were given treatment , and 48 cases of treatment group were given edaravone and conventional treatment for 14 days. Before and after 20 days, patoents in 2 groups were recorded on neurological function feficit scores, efficacy assessment and plasma level of C - reactive protein （CRP）. Results After 20 days, the improvement of neurological function deficit scores of treatment group was superior to control group. And the efficacy of treatment group（ efficiency： 89% ） was higher than control group（ efficiency： 78% ）. The CRP abnormal rate of treatment group （41.38%） were significantly lower than control group （54.35 % ） obviously. Conclusion Edaravone can reduce the inflammatory reaction and decrease the degree of neural function damage on acute cerebral hemorrhage.