摘要
反义寡脱氧核苷酸（ASODN）技术是根据核酸杂交原理，设计针对特定靶序列的ASODN，从而抑制特定基因的表达。分子影像学是一门在细胞与分子水平对活体生物过程进行描述和测量的新兴交叉学科。ASODN技术以分子影像为技术平台，通过图像达到无创、实时、活体、特异、精细地直接显示细胞或分子水平的生理和病理过程。该文主要阐述ASODN的作用机制、ASODN的化学修饰、ASODN技术的进展及其在分子影像领域的应用。
Antisense oligodeoxynucleotide（ASODN） technology is based on nucleic acid hybridization principles, and designed for the specific target of ASODN sequence, thus to inhibit the expression of specific genes. Molecular imaging is the emerging cross-subject in cell and molecular level of living biological processes to describe and measure. Molecular imaging technology as a platform for ASODN technology to reach non-invasive, real-time, live, specific, detailed images directly through the display cells or molecular level physiological and pathological processes. This introductory chapter summarizes the role of ASODN mechanism, chemical modification, ASODN technology progress and ASODN technology in the field of molecular imaging applications.
出处
《国际放射医学核医学杂志》
2009年第1期1-5,共5页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金（30470516）
