应用Rh血型抗原鉴定实现临床输血个体化

Practice clinic individual transfusion by detecting Rh blood group antigen

目的:应用Rh血型抗原鉴定,对Rh阴性患者中存在不规则抗体的输血患者选择相合性输注。方法:对2007年1月-2008年12月检出的RhD阴性输血患者进行D抗原复检、抗体筛查,及对其他Rh血型抗原进行鉴定。结果:在79例RhD阴性的输血患者中抗体筛查阳性的共25例;抗-D抗体3例,抗-E8例,抗-c4例,抗-c、E7例,抗-C1例,抗-e3例,对存在不规则抗体的患者均选择Rh因子相合的血液输注,其中,有7例患者采用O型的ccdEE和CCdee表型红细胞输注。结论:应用抗体筛查及Rh抗原鉴定的结果,选择Rh因子相合的血液输注及对有抗c和抗e抗体的阴性患者在血源困难的情况下选择O型的ccdEE和CCdee表型红细胞输注,保证了特殊血型的用血需求,既可以避免不规则抗体的产生,同时也减少了输血不良反应的发生。

Objective：To choose the matching blood to the clinic RhD negative patients who had irregular antibody by detecting Rh blood group antigen. Method：D antigen, other Rh blood group antigen and irregular antibody of clinic RhD negative patients from January 2007 to December 2008 were detected and analyzed. Result：In 79 cases of RhD negative clinic samples, 25 cases were irregular antibody positive, as well as 3 cases of anti-D, 8 of anti-E, 4 of anti-c, 7 of anti-c and E, 1 of anti-C and 3 of anti-e. The patients who had irregular antibody all received Rh matched blood transfusion, including 7 patients received the O type RBC transfusion with the phenotype of eedEE and CCdee. Conclusion： It could avoid irregular antibody formation and adverse transfusion reaction by choosing the Rh matched blood to the patients who had anti-c and anti-e antibody using antibody screening and Rh blood group antigen detection.