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吉林市汉族妇女GSTM1基因和CYP1A1基因Exon7位点多态性与　子宫内膜异位症易感性的研究 被引量：1

Analysis on the relationship between polymorphism of Exon7 situs in CYP1A1 gene,GSTM1 gene and susceptibility of endometriosis in women of Han nationality in Jilin city
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摘要 目的：探讨在吉林地区汉族妇女中细胞色素P450（CYP1A1）基因Exon7位点多态性即Ile-Val位点的多态性及GSTM1基因多态性和子宫内膜异位症易感性的相关关系。方法：以病例对照的研究方法,采用PCR技术检测216例子宫内膜异位症和216例对照人群的CYP1A1基因Ile-Val位点及GSTM1基因多态性的表达。结果：吉林地区汉族人群中GSTM1空白基因型分布频率0.463,内异症人群中空白基因型分布频率0.667,两组差异有统计学意义（P〈0.05）,空白基因型患内异症的危险是功能基因型的1.896倍;Ile-Val三种多态基因型在内异症组和对照组分布差异有统计学意义（P〈0.05）,Ile/Val、Val/Val基因型患内异症的危险分别是Ile/Ile基因型的1.901倍和3.056倍;CYP1A1 Ile/Val联合GSTM1空白基因型个体的OR值为3.409（95%C I 1.897-6.125,P〈0.01）,而CYP1A1Val/Val联合GSTM1空白基因型个体的OR值增高至7.143（95%C I 2.584-19.742,P〈0.01）。结论：CYP1A1 Exon7的Ile/Val、Val/Val基因型及GSTM1空白基因型与内异症的易感性有关,二者联合效应具有协同作用,可望作为内异症易感人群筛选的重要指标。 Objective： To explore the relationship between polymoq）hism of Exon7 situs （ lie - Val situs） in CYP1A1 gene, GSTM1 gene and susceptibility of endometriosis in women of HaM nationality in Jilin city. Methods： The expression of polymorphisms of Exon7 situs （Ile -Val situs） in CYPI Al gene, GSTM1 gene of 216 cases with endometriosis and 216 healthy women were detected by poly- merase chain reaction （PCR） . Results： The frequencies of GSTMI - null genotype in endometriosis group and control group of HaM nationality were 0. 667 and 0. 463, respectively, there was significant difference （ P 〈 0. 05） , the risk of GSTMI - null genotype to endometriosis was 1. 896 times higher than that of GSTMI ＋ to endometriosis; there was difference in the distribution frequencies of three genotypes of lle/ Val between control group and endometriosis group （ P 〈 0. 05 ） ; the risk of [le/Val and Val/Val to endometriosis was 1. 901 and 3.056 times higher than that of Ile/ Ile genotype to endometriosis; the OR of CYP1A1 Ile/Val combined with GSTMI null geuotypes was 3. 409 （95% CI： 1. 897 -6. 125, P 〈0. 01）, while the OR of CYP1A1 Val/Val combined with GSTM1 null genotypes was 7. 143 （95% CI 2. 584 -19. 742, P 〈 0.01 ） . Conclusion： Ile/Val and Val/Val genotypes and GSTM1 -null genotype are related to the susceptibility of endometriosis, which might be one of the risk factors of endometriosis.
作者 杨丽萍 安晓汾
机构地区 吉林省吉林市中心医院妇产科
出处 《中国妇幼保健》 CAS 北大核心 2009年第18期2556-2559,共4页 Maternal and Child Health Care of China
关键词 子宫内膜异位症 CYP1A1基因 GSTM1基因 多态性 Endometriosis CYP1 A1 gene GSTM1 gene Polymorphism
分类号 R711.71 [医药卫生—妇产科学]
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参考文献11

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二级参考文献21

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中国妇幼保健
2009年 第18期

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