期刊文献+

阿托伐他汀在缺血性脑血管病二级预防中的疗效观察 被引量:8

下载PDF
导出
摘要 目的:观察阿托伐他汀在缺血性脑血管病二级预防中的疗效。方法:135例脑血管病患者随机分为两组,对照组66例予小剂量肠溶阿司匹林常规治疗。治疗组(他汀组)69例口服阿托伐他汀和小剂量肠溶阿司匹林进行脑梗塞的二级预防,随访12个月。结果:他汀组再发暂时性局部脑缺血发作(TIA)、非致死性脑梗死、主要终点发生率分别为5,3,10例,均显著低于对照组14,10,25例,两组比较有统计学差异(P<0.05),死亡率两组比较无显著性差异。结论:联合应用阿托伐他汀和小剂量肠溶阿司匹林可明显降低缺血性脑血管事件,且安全,患者耐受性高。
作者 王欣
出处 《心脑血管病防治》 2009年第3期200-201,共2页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
  • 相关文献

参考文献4

二级参考文献49

  • 1[1]Endo A,Kuroda M,Tsujita Y.ML-236A,ML-236B,and ML-236C,new inhibitors of cholesterogenesis produced by penicillium citrinium[J].J Antibiot,1976,29:1346-1348
  • 2[2]Amarenco P,Labreuche J,Lavallee P,et al.Statins in stroke prevention and carotid atherosclerosis:systematic review and up-to-date meta-analysis[J].Stroke,2004,35:2902-2909
  • 3[3]Ridker PM,Cannon CP,Morrow D,et al.C-reactive protein levels and outcomes after statin therapy[J].N Engl J Med,2005,352:20-28
  • 4[4]LaRosa JC,Grundy SM,Waters DD,et al.Intensive lipid lowering with atorvastatin in patients with stable coronary disease[J].N Engl J Med,2005,352:1425-1435
  • 5[5]Amarenco P.Hypercholesterolemia,lipid-lowering agents,and the risk for brain infarction[J].Neurology,2001,57(Suppl 2):S35-S44
  • 6[6]Aikawa M,Rabkin E,Sugiyama S,et al.An HMG-CoA reductase inhibitor,cerivastatin,suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro[J].Circulation,2001,103:276-283
  • 7[7]Yamada M,Huang Z,Dalkara T,et al.Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment[J].J Cereb Blood Flow Metab,2000,20:709-717
  • 8[8]Nissen SE,Tuzcu EM,Schoenhagen P,et al.Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis:a randomized controlled trial[J].JAMA.2004,291:1071-1080
  • 9[9]Plehn JF,Davis BR,Sacks FM,et al.Reduction of stroke incidence after myocardial infarction with pravastatin:the Cholesterol and Recurrent Events (CARE) Study.The Care Investigators.[J].Circulation,1999,99:216-223
  • 10[10]Amarenco P,Bogousslavsky J,Callahan AS,et al.Design and baseline characteristics of the stroke prevention by aggressive reduction in cholesterol levels (SPARCL)study[J].Cerebrovasc Dis,2003;16:389-395

共引文献33173

同被引文献81

引证文献8

二级引证文献74

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部