纳洛酮对急性酒精中毒患者血浆β-内啡肽水平的影响

Effect of naloxone on the level of plasma β-endorphin in patients with acute alcoholism

目的观察纳洛酮对急性酒精中毒患者血浆β-内啡肽水平的影响。方法将85例急性酒精中毒患者随机分为2组,对照组42例,采用补液利尿常规治疗;实验组43例,在常规治疗的基础上,采用纳洛酮治疗,比较两组疗效和治疗前后1h、2h血浆β-内啡肽水平。结果实验组的治疗持续时间明显短于对照组(P<0.01),治疗后血浆β-内啡肽水平明显低于对照组(P<0.01)。结论纳洛酮能够降低血浆β-内啡肽的水平,用于治疗急性酒精中毒安全有效。

Objective To observe the effect of naloxone on the level of plasma β-endorphin in patients with a-cute alcoholism. Methods 85 patients with acute alcoholism were randomly divided into the experimental group（ n = 43 ）and the control group（ n = 42 ）. Patients in the control group were treated with conventional therapy including fluid replacement plus diuretic agent, and patients in the experimental group were treated with conventional therapy and naloxone. Therapeatic effect of two groups and the level of plasma β-endorphin before treatment and 1 hour,2 hours after treatment were observed. Results The duration of experimental group was obviously shorter than that of control group （P〈0.01） ,and the level of plasma β-endorphin of experimental group was lower than that of control group（P 〈0.01） after treatment. Conclusion Naloxone can reduce the level of plasma β-endorphin it is effective and safe in treating acute alcoholism.