噻托溴铵联合福莫特罗吸入治疗慢性阻塞性肺疾病

Effect of tiotropium bromide inhalation combined with formoterol inhalation on chronic obstructive pulmonary disease

目的观察噻托溴铵联合福莫特罗吸入治疗慢性阻塞性肺疾病(COPD)的效果及安全性。方法46例COPD患者随机分为2组,对照组23例,常规给予福莫特罗治疗;治疗组23例,噻托溴铵联合福莫特罗吸入治疗,疗程4周。观察治疗前、后的临床症状及肺功能变化。结果治疗组对FEV1的改善显著高于对照组(P<0.05)。治疗组减轻日常症状的效果优于对照组。各组均未出现明显不良反应。结论吸入噻托溴铵与福莫特罗联合治疗COPD,疗效优于单药治疗。

Objective To study the effect and safety of tiotropium bromide inhalation combined with formoterol inhalation on chronic obstructive pulmonary disease（COPD）. Methods 46 COPD patients were randomly divided into 2 groups. Treatment group was treated with tiotropium brontide ＋ formoterol ;control group was treated with formoterol. The course was 4 weeks. The symptoms and lung function were observed before and after treatment. Results There were significant differences in the symptoms and FEV1 between 2 groups（P〈0.05）. No significant adverse reac- tion was found. Conclusion The therapeutic effect of tiotropium bromide inhalation and formoterol inhalation on COPD is better than that of tiotropium.