艾司西酞普兰与氟西汀治疗抑郁症对照研究

A comparative study of escitalopram and fluoxetine in the treatment of depression

目的:比较艾司西酞普兰与氟西汀治疗抑郁症的疗效和安全性。方法:将80例抑郁症患者随机分为两组,分别给以予艾司西酞普兰与氟西汀治疗,疗程6周。用汉密尔顿抑郁量表(HAMD)在治疗前及治疗1、2、4、6周评定疗效,用副反应量表(TESS)评定不良反应。结果:两组总体疗效相当,艾司西酞普兰组HAMD评分从第1周就开始显著下降,而氟西汀组HAMD评分从第2周开始显著下降;治疗6周艾司西酞普兰组有效率82.5%,显效率75.0%,氟西汀组分别为80.0%和72.5%。两组不良反应均较轻,安全性好。结论:艾司西酞普兰抗抑郁作用起效较快,疗效及不良反应与氟西汀相当。

Objective To compare the clinical efficacy and safety of escitalpram and fluoxetine in the treatment of depression. Method Eighty patients with depression were treated randomly with escitalopram or fluoxetine for a course of treatment of six weeks, and measured with Hamilton Depressive Scale （HAMD） for efficacy, and Treatment Emergent Symptom Scale （TESS） for side effect before treatment and 1,2, 4, 6 weeks after treatment. Results There was no significant difference in efficacy between the two groups. HAMD scores decreased dramatically at the end of 1st week in escitalopram group and 2nd week in fluoxetine group. The rates of efficacy and marked im- prevement in escitalopram group were 82.5% and 75.0 %, and that in fluoxetine group were 80. 0% and 72.5 %. The side effects of both were fewer. Conclusion Both eseitalopram and fluoxetine are effective antidepressants with fewer side effect. However, eseitalopram takes effect more quickly.