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益赛普与甲氨蝶呤联合应用治疗类风湿性关节炎 被引量:3

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摘要 类风湿性关节炎(Rheumatoid Arthritis,RA)是一种由免疫、内分泌、感染、遗传、环境等多因素参与的全身性自身免疫性疾病。该病呈全球分布,我国患病率为0.32%-0.36%,西方国家为1%。迄今为止,针对RA临床上尚缺乏根治方法和预防措施。由于它最终导致关节畸形及功能障碍,增加社会和经济负担,因此对它的研究也就变得更加迫切。
出处 《吉林医学》 CAS 2009年第11期1040-1041,共2页 Jilin Medical Journal
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参考文献3

  • 1中华医学会风湿病学分会.类风湿关节炎诊治指南.中华风湿病学杂志,2005,9:3-3.
  • 2Maini RN,Breedveld FC.Sustained improvement over two years in physical function,structural damage,and signs and symptoms among patients with rheumatoid arthritis treated with infliximab and methotrexate[J].Arthritis Rheum,2004,50(4):1051.
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同被引文献24

  • 1何敏华,杨毅梅.来氟米特治疗难治性类风湿关节炎临床疗效观察[J].中国药物与临床,2005,5(5):391-391. 被引量:1
  • 2黄建林,吉洁若,赵丽珂,余步云,李天旺.重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白治疗类风湿关节炎有效性和安全性研究[J].中国药物与临床,2006,6(7):543-545. 被引量:10
  • 3Iain BM,Georg S. Cytokines in the pathogenesis of rheu- matoid arthritis[J]. Nature Reviews Immunology, 2007,7 (3):429-442.
  • 4van OM, Levarht EW, Sont JK, et al. Ciiaical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12[J]. Ann Rheum Dis,2005,64(4) :537-543.
  • 5van VRF,Geborek P, Forslind K, et al. Conventional com- bination treatment versus biological treatment in methotrex- ate- refractory early rheumatoid arthritis :2 year follow-up of the randomised, non-blinded, parallel- group Swefot trial[J]. Lancet, 2012,379 (9827):1712- 1720.
  • 6Antony T,Jose VM,Paul BJ,et al. Efficacy and safety of leflunomide alone and in combination with methotrexate in the treatment of refractory rheumatoid arthritis[J]. In- dian J Med Sci,2006,60(8) :318-326.
  • 7Kekow J, Moots R J, Emery P, et al. Patient-reported out comes improve with etanercept plus methotrexate in ac- tive early rheumatoid arthritis and the improvement is strongly associated with remission:the COMET trial[J]. Ann Rheum Dis,2010,69(1) :222-225.
  • 8Symmons DP,Silman AJ. The world of biologics[J]. Lu- pus, 2006,15 (3) : 122-126.
  • 9Clelland S, Hunek JR. Etanercept injection site reaction [J].Dermatology Nursing, 2005,17 (5) : 375-380.
  • 10于学满,王晓非.益赛普与传统方法治疗类风湿关节炎疗效分析[J].中国误诊学杂志,2008,8(3):567-568. 被引量:7

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