血清淀粉样蛋白A与慢性阻塞性肺病急性加重期的关系及临床意义

The relationship between serum amyloid A and acute exacerbations of chronic obstructive pulmonary disease and its clinic significance

目的观察慢性阻塞性肺病急性加重期(AECOPD)患者的血清淀粉样蛋白A(SAA)、C反应蛋白(CRP)水平变化以及临床意义。方法选择56例AECOPD患者,检测入院时、缓解时、稳定期及对健康对照者SAA、CRP。结果(1)入院时SAA、CRP显著高于稳定期及正常对照组(P值均<0.05);(2)Ⅲ级组入院时SAA水平较Ⅰ/Ⅱ级组显著升高(P<0.05),CRP无显著差异;(3)治疗失败组入院时SAA水平较治疗缓解组显著升高(P<0.05),CRP无显著差异;(4)入院时SAA水平与住院时间有显著正相关性,CRP无相关性。结论本研究表明SAA可作为AECOPD的炎症标志物。

Objective To investigate the changes of SAA and CRP levels and its clinic significance.Methods Total 56 cases of AECOPD were selected, SAA and CRP was determined respectively on the time of admission ,resolution of AECOPD and stable period, also obtained in volunteers.Results （1） SAA, CRP levels on admission were significantly higher than that of stability period and the normal group （P〈0.05）; （2）SAA of level Ⅲ group on admission was significantly higher than on level Ⅰ / Ⅱ group（P〈0.05）; no significant difference in CRP; （3）SAA levels on admission according to treatment failure group was significantly higher than resolution group（P〈0.05）, CRP was no significant difference;（4） there was a positive association between the length of hospital stay and SAA levels on admission,CRP levels have no such correlation.Consclusion Our data suggesting SAA could be used as a inflammation marker for AECOPD.