乙交酯与2-氢-2-氧-1,3,2-二氧磷杂环己烷的开环共聚研究

Studies on Ring opening copolymerization of Glycolide and 2-Hydro-2-oxo-1,3,2-dioxaphosphorinane

聚乙醇酸及其与乳酸的共聚物是一类无毒、有良好的生物相容性和生物可降解材料,它们广泛地用作药物控释体系的载体,牙科植入材料[1,2].但由于聚乙醇酸的高度可结晶性,使其不溶于包括三氟乙酸在内的几乎所有的有机溶剂,因此通过共聚来改进其物化性质的研究一直方...

A novel kind of copolymers was synthesized by ring opening copolymerization of glycolide and 2 hydro 2 oxo 1,3,2 dioxaphosphorinane,using triisobutylaluminium as the initiator. Their structures were confirmed by 1H NMR and FTIR. The influence of molar ratio of monomers and time on the total conversion, copolymer composition and molecular weight were investigated, respectively. The crystallinity degree and cell dimensions of the copolymers were determined by XRD.