微乳中复凝聚法制备壳聚糖-明胶纳米胶囊

Nanocapsules Preparation by Complex Coacervation in Microemulsion With Chitosan-gelatin

以明胶和壳聚糖作为包裹材料，在O／W型微乳液模板中，用复凝聚的方法制备纳米胶囊，考察了影响合成纳米胶囊的主要因素，并进行了分析．结果表明，本实验采用的在微乳中复凝聚法合成了分散性好、粒度均匀、粒径200—400nm的球形纳米胶囊．制备了尼莫地平（NMP）纳米胶囊，得到包封率达到90％、粒径500～800nm的载药纳米胶囊．

Nanocapsules were prepared in O/W microemulsion by complex coacervation of chitosan and gelatin. The preparation conditions of polymeric nanocapsules were analyzed. The results demonstrate that the nanocapsules with size of 200 -400 nm are spherical with uniform particle diameter distribution. Nanoeapsule drug carrying NMP was prepared, and the nanoeapsules with size of 500 - 800 mn have entrapment efficiency of 90%.