摘要
以明胶和壳聚糖作为包裹材料,在O/W型微乳液模板中,用复凝聚的方法制备纳米胶囊,考察了影响合成纳米胶囊的主要因素,并进行了分析.结果表明,本实验采用的在微乳中复凝聚法合成了分散性好、粒度均匀、粒径200—400nm的球形纳米胶囊.制备了尼莫地平(NMP)纳米胶囊,得到包封率达到90%、粒径500~800nm的载药纳米胶囊.
Nanocapsules were prepared in O/W microemulsion by complex coacervation of chitosan and gelatin. The preparation conditions of polymeric nanocapsules were analyzed. The results demonstrate that the nanocapsules with size of 200 -400 nm are spherical with uniform particle diameter distribution. Nanoeapsule drug carrying NMP was prepared, and the nanoeapsules with size of 500 - 800 mn have entrapment efficiency of 90%.
出处
《南京师大学报(自然科学版)》
CAS
CSCD
北大核心
2009年第2期69-72,共4页
Journal of Nanjing Normal University(Natural Science Edition)
基金
国家自然科学基金(20673059)
江苏省普通高校自然科学研究计划(07KJD150099)资助项目
关键词
微乳液
复凝聚
壳聚糖
明胶
纳米胶囊
尼莫地平
microemulsion, complex coacervatiou, chitosan, gelatin, nanocapsule, NMP