高密度脂蛋白胆固醇与冠心病及其危险因素的回顾性分析

Retrospective analysis of the association between HDL-C and coronary heart disease and risk factors of coronary heart disease

目的:探讨高密度脂蛋白胆固醇(HDL-C)与冠心病、冠心病危险因素的关系。方法:将931份心脏科住院病例按HDL-C水平分为3组,小于1.04 mmol/L为低水平组,1.04～1.54 mmol/L为适当水平组,大于等于1.55 mmol/L为高水平组,对3组资料进行回顾性分析。结果:甘油三酯(TG)、动脉粥样硬化指数、尿酸(UA)、血糖、急性心肌梗死和2型糖尿病患病率高水平组和(或)适当水平组明显低于低水平组(P<0.05),高水平组较适当水平组2型糖尿病和急性心肌梗死患病率、随机血糖、低密度脂蛋白(LDL)无显著差异(P>0.05)。3组病人的住院天数、高血压、心律失常、冠心病患病率无明显差别(P>0.05)。高水平组总胆固醇(TC),收缩压最高(P<0.05)。结论:虽然高水平、适当水平组较低水平组心血管保护作用明显,但高水平组较适当水平组心血管保护作用不显著。高密度脂蛋白胆固醇的质量比数量重要。

Objective： To study the relationships between HDL-C and coronary heart disease（CHD） and CHD risk factors. Methods： All data were taken from 931 patients admitted to the department of cardiology. The patients were divided into 3 groups according to the level of HDL-C, which were designated low （〈1.04 mmol/L）, normal （1.04- 1.54 mmol/L） or high（〉1.54 mmol/L）. The demographics and CHD risk factors？for each group were analyzed. Results： The level of TG, LDL-C/HDL-C, uric acid （UA）, blood sugar, rates of type 2 diabetes and acute myocardial infarction（AMI） in the high and/or normal groups were lower than those of the low HDL-C group （P 〈0.05）. Compared with those of normal HDL-C, the high HDL group had no significantly decrease in type 2 diabetes and AMI, random blood sugar , LDL （P〉0.05）.Tbe length of hospital stay, rates of CHD, hypertension and arhythemia were not statistical different among the three groups （P〉0.05）, while the high HDL-C group had on average the greatest level of TC, systolic blood pressure （SBP）. Conclusion： Although compared with low HDL-C group, normal and high HDL-C group provide obvious protection against CHD, elevated HDL-C above normal levels do not provide obvious protection .HDL-C＇ quality is more important than its quantity.