摘要
目的:观察OSAS患者体内炎症因子的水平与OSAS合并高血压的关系。方法:用PSG检查诊断重度OSAS患者60例,其中32例合并高血压病。用ELISA方法检测OSAS患者血清中TNF-α、IL-6、IL-10的水平。结果:OSAS合并高血压患者TNF-α和IL-6水平均显著高于OSAS患者和正常对照组,而IL-10水平在三组中的水平呈逐渐降低,OSAS合并高血压患者IL-10水平低于OSAS患者和正常对照组。结论:同等严重程度的OSAS患者体内细胞因子水平并不相同,这种差异在高血压的形成方面可能具有重要作用。
Objective: To observe the correlation between interleukin level and hypertension in patients with obstructive sleep apnea syndrome (OSAS). Methods: OSAS was diagnosed with PSG method and serum levels of TNF-α,IL-6,IL-10 were measured by ELISA. Results: The serum levels of TNF-α and IL-6 were higher in OSAS patients with hypertension than in those without hypertension. However, the serum level of IL-10 was lower in OSAS patients with hypertension than in those without hypertension. Conclusion: The interleukin levels are different in severe OSAS patients, which may play a role in the development of hypertension in OSAS patients.
出处
《军医进修学院学报》
CAS
2009年第3期349-350,共2页
Academic Journal of Pla Postgraduate Medical School
基金
国家973重点基础研究发展规划项目(G2000057004)
解放军总医院苗圃基金项目(06MP50)~~