RNA干涉技术在糖尿病肾病研究中的应用进展
Application of RNA interfere technology in research of diabetic nephropathies
摘要
RNA干涉技术自发现以来进展迅速,并凭借其技术特点已成为研究基因功能和基因治疗的有力工具。而糖尿病肾病发病率逐年升高,至今发病机制不清,治疗效果欠佳,RNA干涉技术作为一项新手段,正在其机制研究及治疗干预中逐渐发挥重要作用。
出处
《军医进修学院学报》
CAS
2009年第3期403-404,共2页
Academic Journal of Pla Postgraduate Medical School
参考文献9
-
1Fire A,Xu S,Montgomery MK,et al.Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans[J].Nature,1998,391:806-811.
-
2Hannon GJ.RNA interference[J].Nature,2002,418:244-251.
-
3Stevens VA,Saad S.The role of SGK-1 in angiotensin H-mediated sodium reabsorption in human proximal tubular cells[J].Nephrol Dial Transplant,2008,23 (6):1834-1843.
-
4Furlong F,Crean J.Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose[J].Am J Physiol Renal Physiol,2007,292(6):F1691-1700.
-
5Qi W,Chen X.High glucose induces macrophage inflammatory protein-3 alpha in renal proximal tubule cells via a transforming growth factor-beta 1 dependent mechanism[J].Nephrol Dial Transplant,2007,22(11):3147-3153.
-
6Nob HJ,Kim HC.The inhibitory effect of siRNAs on the high glucose-induced overexpression of TGF-beta1 in mesangial cells[J].J Korean Med Sci,2006,21(3):430-435.
-
7Takabatake Y,Isaka Y,Mizui M,Exploring RNA interference as a therapeutic strategy for renal disease[J].Gene Ther,2005,12(12):965-973.
-
8Burns WC,Twigg SM.Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition:implications for diabetic renal disease[J].J Am Soc Nephrol,2006,17(9):2484-2494.
-
9Mima A,Matsubara T.Anglotensin Ⅱ-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy[J].Lab Invest,2006,86(9):927-939.
-
1孔秀英,孙秀杰.基因治疗[J].生物学杂志,1994,6(3):12-14. 被引量:2
-
2王永升,CarolEzzell.杀灭信使RNA—关闭信使RNA可能会阻止癌症和艾滋病[J].科学(中文版),2002(10):14-14.
-
3土豆不土[J].家庭医药(就医选药),2005(4):32-32.
-
4林善锬.糖尿病肾病研究中的几个值得重视的问题[J].中华肾脏病杂志,2004,20(3):151-153. 被引量:61
-
5林善锬.糖尿病肾病研究的几个关键[J].中华肾脏病杂志,2000,16(2):69-70. 被引量:44
-
6张新颖,钱秋海,王营营.单味中药及其提取物治疗糖尿病肾病研究进展[J].云南中医中药杂志,2013,34(12):84-85. 被引量:3
-
7廖昆,尹卫东,欧秋娟,何勇,曹明艳.金水宝胶囊预防造影剂肾病研究[J].湘南学院学报(医学版),2011,13(1):28-29. 被引量:4
-
8杨红斌.肾素-血管紧张素系统在糖尿病肾病研究探析[J].大家健康(学术版),2013(4):121-121. 被引量:1
-
9韩庆奇,张宝仁.心血管疾病基因治疗进展[J].岭南心血管病杂志,2003,9(6):441-444.
-
10封玥,高锦声.遗传病的治疗原则[J].中国计划生育学杂志,2000,8(10):479-480.