DrugFET的研究(Ⅳ).硅钨酸-麻黄碱FET的研制与应用

Studies on DrugFET(Ⅳ):The Development and Application of Silicotungstic acidEphedrine FET

将离子敏感场效应晶体管（ＩＳＦＥＴ）与药物敏感膜相结合，研制成一种对盐酸麻黄碱有良好响应的药物敏感场效应晶体管传感器（ＤｒｕｇＦＥＴ）。该器件具有全固态化，体积小，易微型化，集成化和多功能化，响应快速和低输出阻抗等优点。采用硅钨酸作为电活性物质，不必转型，制成ＰＶＣ膜ＩＳＦＥＴ，对麻黄碱响应的线性范围是１．０×１０－１～５．０×１０－６ｍｏｌ／Ｌ，斜率为５９ｍＶ／ｐｃ（ｃ＝ｍｏｌ／Ｌ），检测下限为２．０×１０－６ｍｏｌ／Ｌ，适宜ｐＨ值范围为４．５～８．０。利用该传感器分析盐酸麻黄碱片剂的含量，结果和药典分析方法相一致。

This paper is about the development of a kind of DrugFET sensors of ephedrine hydrochloride by the combination of ISFET and drug sensitive membranes.Itis a solidstate of small size and can be miniatured ,integrated,gives fast response and low output impedance.Also ,electronic circuits can be nonolithically integrated with devices to produce“smart sensors”.The paper describes a new ephedrineFET,which is based on using silicotungstic acid as the active material.The sensor exhibits Nernstian response for ephedrine cation with a slope of 59mV/decade(15℃) over the concentration range of 5.0×10-6～1.0×10-1mol/L at pH 4.5～8.The detection limit is 2.0×10-6mol/L.The sensor shows fast response,good reproducibility and stability.It has been used for the determination of ephedrine in medicinal tablet.The results obtained agree with those by the pharmacoeia method