(R)-N-(β-三氯锗取代丙酰基)TTCA酯的合成及其倍半氧化物

Synthesis of the (R)-N-(β-Trichlorogermyl Substituted Propionyl)TTCA Ethers and Their Sesquioxides

β-三氯锗取代丙酰氯1a～1c与(R)TTCA酯反应,得到光学活性的(R)-N-(β-三氯锗取代丙酰基)TTCA酯3a～3d[α]_D^(20)-86.00～-94.35°)及光学活性的β-三氯锗取代丙酰氯2a～2d。化合物3a～3d经水解得到(R)-N-(β-取代丙酰基)TTCA酯基锗倍半氧化物4a～4d,[α]_D^(20)-44.48～-77.00°。用半经验量子化学MNDO方法研究了反应物和产物最优构型的电子结构及反应的焓变。

The (R) - N - (B- trichlorogermyl substituted propionyl)thiazolidine - 2 - thione - 4 - carboxylic acid ethers [(R) - N - (B- trichlorogermyl substituted propionyl)TTCA ethers]3a~ 3d, [a]20D-86.00-- 94.35 and optically active B- trichlorogermyl substituted propionyl chloride 2a --2d were synthesized by the reaction of trichlorogermyl substituted propionyl chloride with (R) -thiazolidine - 2 - thione - 4 - carboxylic acid ethers [ ( R )TTCA ethers]. The (R ) - N - (substituted propionyl thiazolidine - 2 - thione - 4 - alkyloxycarbonyl) germanium sesquioxides 4a^4d, [a]20D - 44.48--77.00 were obtained by the hydrolysis of compounds 3a^3d. The electronic structure of reactants and products have been studied by quantum chemisty MNDO method. Reactive enthalpy H have been obtained.