毛细管区带电泳碳纤维电极电化学检测氯丙嗪

Determination of Chlorpromazine by Capillary Zone Electrophoresis With Electrochemical Detection at a Carbon Fiber Electrode

用毛细管区带电泳／电化学检测器检测了氯丙嗪。在最佳实验条件下，测定氯丙嗪的线性范围为５×１０－７～１×１０－４ｍｏｌ／Ｌ；检测限为１×１０－７ｍｏｌ／Ｌ（３８０ａｍｏｌ）。此方法已应用于模拟尿样中氯丙嗪的测定。

Capillary zone electrophoresis was empolyed to the analysis of chlorpromazine using an end-column amperometric detector with a carbon fiber electrode. The optimum conditions of separation and detection are 6. 48× 10-3 mol/L Na2HPO4-1. 52× 10-3 mol/L NaH2PO4, 3 kV for the separation voltage and 0. 72 V (vs. SCE) for the detection potential. The limit of detection is 1× 10-7 mol/L or 380 amol. The method was applied to the determination of chlorpromazine in human urine.