摘要
对PPAR-γ的激动剂及其在动脉粥样硬化中对血管细胞的影响等方面进行综述。过氧化物酶体增殖物激活受体-γ(peroxisome proliferator-activated receptor-γ,PPAR-γ)几乎对参与动脉粥样硬化的所有血管细胞均有影响,在调节动脉粥样硬化的发生中起重要的作用。PPAR-γ与特异性激动剂结合后,调节靶基因的转录活性,抑制血管细胞的增殖与迁移,降低炎症反应,阻止动脉粥样硬化的发生。
The agonists of PPAR - γ and the effect on vascular ceils in atherosclerosis are reviewed. Atherosclerosis （AS） is an inflammatory process of vascular injure. It has been shown that peroxisome proliferator - activated receptor - （ PPAR - γ） plays a crucial role in AS, which affects nearly all vascular cells participated in AS. PPAR - γ binding specific agonists regulates transcriptive activity. PPAR - γ suppresses the proliferation and migration of vascular cells, degrades inflammatory reaction, and prevents the development of atherosclerosis.
出处
《大连大学学报》
2009年第3期87-91,共5页
Journal of Dalian University
基金
国家自然科学基金项目资助(30371380
30571733)
