慢性冷水游泳应激对小鼠空间学习记忆和海马NO、NOS的影响

Effects of chronic cold water swimming stress on spatial learning-memory and NO,NOS in hippocampus of mice

32只成年昆明种小鼠随机分成对照组和应激组,采用强迫冷水游泳建立慢性应激动物模型,Morris水迷宫行为实验观察动物的空间学习记忆能力,同时测定海马NO含量及NOS活性。结果表明,慢性冷水游泳应激可提高小鼠空间学习记忆能力,其机制可能与海马NO含量和NOS活性降低有关。

32 adult KunMing mice were divided into control group and stress group randomly. Chronic stress model was established by forcing cold water swimming. Morris water maze was used to observe spatial learning and memory abilities. Contents of NO and NOS activity in hippocampus were measured during the test. The results showed that chronic cold water swimming stress could improve the spatial learning and memory abilities in mice. Its effects may be involved in the decrease of the content of NO in hippocampus.