摘要
人类滋养细胞是有异于体细胞的特殊细胞,具有独特的分化特点和生物学特性,恶性滋养细胞肿瘤的主要特征是滋养细胞的侵袭与转移,随着分子生物学技术的发展,研究发现多种因素参与滋养细胞的侵袭与转移过程。从原癌基因、抑癌基因、黏附分子、细胞因子、信号传导、细胞增殖、细胞凋亡、细胞周期调控、特异蛋白等多方面综述滋养细胞浸润转移机制的研究进展。
Human trophoblast cells have special biological and differentiation characteristics different from somatic ceils. The main features of malignant trophoblast tumors are invasion and metastasis. With the development of molecular biological techniques, a variety of factors participated in the process of invasion and metastasis of trophoblast cells have been found. This article reviews the new advances in the mechanisms of invasion and metastasis of trophoblast cells from proto-oncogenes, tumor suppressor genes, adhesion molecules, cytokines, signal transduction, cell proliferation, apoptosis, cell cycle regulation and specific proteins.
出处
《兰州大学学报（医学版）》
CAS
2009年第2期101-104,共4页
Journal of Lanzhou University（Medical Sciences）
关键词
滋养细胞肿瘤
浸润
转移
trophoblast tumor
invasion
metastasis
