抗菌肽研究进展

Advanc in Antimicrobial Peptides

抗菌肽是指存在于生物体内能抵抗外界微生物侵害,消除体内突变细胞的一类小分子多肽。自从Boman从天蚕蛹中分离出抗菌肽cecropin后,已在多种生物体内发现并分离出多种不同类型的抗菌肽,按其结构可分为4类。抗菌肽对微生物具有广谱抗菌作用,但其分离和合成的成本昂贵。用基因工程方法生产抗菌肽是将其大规模应用的有效手段,其中巴斯德毕赤酵母是最有效的表达体系之一。

Antimicrobial peptides refer to a variety of small molecule of peptides existing in the organisms which can improve the defense against external microbial infection and eliminate in vivo mutation in cells. According to their structures, four types of antimicrobial peptides had been classified, and isolated from diverse organisms since the isolation of cecropin from the pupa of Hyatophoracecropia by Boman. These peptides are broad-spectrum anti-pathogen, but the application was limited by the high cost of purification and synthesis. A facilitated method in large-scale production of the antimicrobial peptides was via the gene engineering, in which Pichia pastoris is one of the most effective systems.