高血压病患者血脂、尿酸与胆红素水平变化及其临床意义

Changes of serum lipid,urinary acid and bilirubin in patients with essential hypertension and its significance.

目的探讨高血压病(EH)患者血脂、血尿酸(UA)和总胆红素(T-BIL)水平变化及其临床意义。方法测定69例高血压病患者(EH组)及40例健康者(对照组)总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、总胆红素(T-BIL)和尿酸(UA)含量及24 h平均脉压(MPP)。结果EH组TC、LDL-C、UA及MPP均显著增高(P<0.01),差异有统计学意义;EH组T-BIL、HDL-C低于对照组(P<0.05,P<0.01),差异有统计学意义;相关分析显示:MPP值与TC、LDL-C、UA呈正相关,与HDL-C呈负相关。结论血脂、胆红素、尿酸水平的变化在高血压的发病中起重要作用。

Objective To investigate the role of changes of serum lipid, bilirubin and urinary acid in patients with essential hypertension （EH） and clinic significance. Methods The levels of serum total cholesterol （TC）, triglycerides （TG）, high density lipoprotein （HDL-C）, low density lipoprotein （LDL- C）, total bilirubin （T- BIL） , urinary acid （UA） and mean pulse pressure （MPP） were measured respectively in 69 patients with essential hypertension （ EH group） and 40 health controls （ control group）. Results The levels of serum TC, LDL - C and UA in EH group were significantly higher than those in control group （ P 〈0.01 ） , while the levels of serum T- BIL, HDL- C in EH group were significantly lower than those in control group （ P 〈 0.05, P 〈 0.01 ）. There was a positive relation between the level of TC, LDL - C, UA and the degree of MPP, while there was a negative relation between the level of HDL - C and the degree of MPP. Condusion Serum lipid, bilirubin and urinary acid may play an important role in initiation and progression of essential hypertension.