星蒌承气汤治疗缺血性中风病临床疗效观察

Curative effect of Xinglouchengqi Decoction on ischemic stroke

目的观察星蒌承气汤治疗急性缺血性中风病痰热腑实证的临床疗效,并通过高敏C-反应蛋白(Hs-CRP)的测定,探讨其疗效机制。方法将56例急性缺血性中风病痰热腑实证的患者随机分为治疗组28例、对照组28例。在给予活血化瘀、抗血小板聚集等常规治疗的基础上,治疗组给予中药星蒌承气汤,对照组针对便秘给予开塞露纳肛治疗,疗程均为1周。观察2组治疗前后中医证候评分、神经功能缺损程度评分及血清Hs-CRP的变化。结果治疗后风证、火热证、痰证评分治疗组、对照组与本组治疗前比较均有差异;火热证评分2组间比较有差异。治疗组Hs-CRP水平明显改善,优于对照组。结论星蒌承气汤治疗急性缺血性中风病痰热腑实证有较好的临床疗效,推测作用机制可能与其能减轻脑缺血炎性损伤、改善脑循环有关。

Objective To observe the curative effect of Xinglouehengqi Decoction on the phlegm-heat and fu-excess syndrome of ischemic stroke, and discuss the mechanism through detecting changes of high-sensitivity C-reactive protein （Hs-CRP）. Method The patients with the phlegm-heat and fu-excess syndrome of ischemic stroke （n=56） were randomly divided into the treatment group （n=28） and control group （n=28）. On the base of routine treatment, including the therapy of activating blood circulation and resolving stasis and inhibiting platelet aggregation, the treatment group was given Xinglouehengqi Decoction and control group was given anus injection of Kaiselu to treat astriction. The treatment course was one week. The scores of TCM syndromes, scores of neurological deficits and changes of serum Hs-CRP were observed in two groups before and after the treatment. Result After the treatment the scores of wind syndrome, fire-heat syndrome and phlegm syndrome were different in two groups compared respectively with those in two groups before the treatment. There was a difference in the scores of fire-heat syndrome between two groups. The changes of Hs- CRP were improved more significantly in the treatment group than in the control group. Conclusion Xinglouchengqi Decoction has a better curative effect on the phlegm-heat and fu-excess syndrome of ischemic stroke, and the mechanism may be related to that it can relieve the inflammatory lesion of brain ischemia and improve cerebral circulation.