颅脑损伤血浆降钙素基因相关肽含量变化及法医学意义

Change of CGRP level in patients with craniocerebral trauma and its medicolegal significance

目的研究颅脑损伤患者血浆中降钙素基因相关肽(CGRP)水平变化,观察其与颅脑损伤之间的关系并探讨其在颅脑损伤中的作用。方法40例脑外伤患者,其中轻中型(GCS评分9～15分)、重型(GCS评分3～8分)各20例。采用酶联免疫法测定患者伤后第1、3、5、7d及25例体检健康的志愿者血浆中CGRP水平。结果颅脑损伤患者与正常对照组比较血浆中CGRP水平明显增高,除轻中度组第7d外,均有显著性差异(P<0.05);且重度组在3d内高于轻中度组,有显著性差异(P<0.05)。结论颅脑损伤者CGRP水平增高,且因病情加重会进一步升高,但随时间的延长有下降趋势。

Objective To investigate the relation between the change of calcitonin gene related peptide （CGRP） level and severity of injury in patients with craniocerebral trauma. Methods 65 cases were collected including 40 patients with craniocerebral trauma and 25 health volunteers as control. Of 40 patients, 20 were evaluated as having severe craniocerebral trauma （GCS： 3 -8 ） , and 20 as having minor or moderate （GSC： 9 - 15）. The level of CGRP was dtermined at the first, the third, the fifth and the seventh day, respectively by euzyme-linked immunosorbent assay. Results Plasma levels of CGRP in patients with craniocerebral trauma were higher than those in healthy volunteers, which were statistically significant （P 〈 0.05 ） with exception in those with minor or moderate craniocerebral trauma at the seventh day. Level of CGRP was obviously elevated in patients with severe craniocerebral trauma than in those with minor or moderate craniocerebral trauma within 3 day post-trauma （ P 〈 0.05 ）. Conclusions The result suggests that CGRP level is elevated in patients with craniocerebral trauma, and profoundly increased with exacerbation of the condition, which may be reduced with extension of the post-traumatic interval.